Journal Articles

• Pressure Ulcers—'A Sore Subject: Anatomy of a Killer'
  Article used with permission of United Spinal Association (www.unitedspinal.org).

Selected Publications

• Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J.. Prevention and Reversal of Diabetic Nephropathy in db/db Mice Treated with Alagebrium (ALT-711). Am J Nephrol. 2006 Sep 13;26(5):430-436
• Brem H. Sheehan P. Rosenberg HJ. Schneider JS. Boulton AJ. Evidence-based protocol for diabetic foot ulcers. Plastic & Reconstructive Surgery. 117(7 Suppl):193S-209S; discussion 210S-211S, 2006 Jun.
• Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M. Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing.Am J Pathol. 2005 Jul;167(1):59-69.
• Jho SH, Vouthounis C, Lee B, Stojadinovic O, Im MJ, Brem H, Merchant A, Chau K, Tomic-Canic M.The book of opposites: the role of the nuclear receptor co-regulators in the suppression of epidermal genes by retinoic acid and thyroid hormone receptors. J Invest Dermatol. 2005 May;124(5):1034-43.
• Lee B, Vouthounis C, Stojadinovic O, Brem H, Im MJ, Tomic-Canic M. From an Enhanceosome to a Repressosome: Molecular Antagonism between Glucocorticoids and EGF Leads to Inhibition of Wound Healing. Journal of Molecular Biology. .2005; 345(5):1083-97.
• Brem H, Kirsner RS, Falanga V: Protocol for the successful treatment of venous ulcers. American Journal of Surgery. 2004;188: 1-8.
• Wallenstein S, Brem H: Statistical analysis of wound healing rates for pressure ulcers. American Journal of Surgery. 2004;188: 73-8.
• Tomic-Canic M, Brem H: Gene array technology and pathogenesis of chronic wounds. American Journal of Surgery. 2004;188: 67-72.
• Freedman G, Brem H: Practical treatment of pain in patients with chronic wounds: a pathogenesis-guided management. American Journal of Surgery. 2004;188: 31-5.
• Brem H, Kirsner RS, Falanga V .. Protocol for the successful treatment of venous ulcers. Am J Surg. 2004 Jul;188(1A Suppl):1-8. Review.
• Brem H, Lyder C: Protocol for successful treatment of pressure ulcers. American Journal of Surgery. 2004;188: 9-17.
• Brem H, Sheehan P, Boulton AJM: Protocol for the treatment of diabetic foot ulcers. American Journal of Surgery. 2004;187:1-10.
• Brem H, Gill K, Tarnovskaya A, Ehrlich HP, Carasa M, Weinberger S, Baskin-Bey E, Tomic-Canic M, Vladeck B. Healing of Elderly Patients with Diabetic Foot Ulcers, Venous Stasis Ulcers, and Pressure Ulcers. Surgery Technology International. 2003; XI: 161-167.
• Peppa M, Brem H, Zhang J, Cai W, Vlassara H. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 2003 Nov;52(11):2805-13.
• Freedman G, Cean C, Duron V, Tarnovskaya A, and Brem H. Pathogenesis and Treatment of Pain in Patients with Chronic Wounds. Surgery Technology International. 2003; XI: 23-31 168-182.
• Brem H, Jacobs T, Vileikyte L, Weinberger S, Gibber M, Boulton A. Wound Healing Protocols for Diabetic Foot and Pressure Ulcers. Surgery Technology International. 2003; XI: 85-96.
• Brem H, Young J, Tomic-Canic M, Isaacs C, Ehrlich, H.P. Clinical Efficacy and Mechanism of Bilayered Living Human Skin Equivalent in the Treatment of Diabetic Foot Ulcers. Surgery Technology International. 2003; XI: 23-31.
• Willis A, Gibber M, Moore S, Brem H. Sickle Cell Disease and Leg Ulcers: Pathogenesis, Complications, Assessment, and Treatment. In Wound Care Essentials, ed. by Elizabeth Ayello and Sharon Baronski. 2003.
• Brem H, Nierman DM, Nelson JE.Pressure ulcers in the chronically critically ill patient. Crit Care Clin. 2002 Jul;18(3):683-94. Review.
• Brem H, Nelson J, Nierman, D: Treatment of Pressure Ulcers in the Intensive Care Unit. Critical Care Clinics of North America, 2002;Vol.18, issue 3:1-12.
• Kerstein MD, Brem H, Giovino KB, Sabolinski M.Development of a severity scale for evaluating the need for Graftskin in nonhealing venous ulcers. Adv Skin Wound Care. 2002 Mar-Apr;15(2):66-71.
• Brem H. Specific Paradigm for Wound Bed Preparation in Chronic Wounds. In Cherry GW, Harding KG, Ryan TJ, Editors. Wound Bed Preparation. The Royal Society of Medicine Press Ltd. University of Oxford, UK. 2001; 33-39.
• Falanga V, Brem H. Wound Bed Preparation for Optimal Use of Advanced Therapeutic Products. In Falanga V, Editor. Cutaneous Wound Healing. Boston University Press, 2001; 457-468.
• Brem H, Balledux J, Sukkarieh T, Falanga V. Healing of Venous Ulcers of long Duration with a Bilayered Living Skin Substitute: Results from a General Surgery and Dermatology Department. Dermatologic Surgery. 2001 Nov; 27(11):915-9.
• Brem H, and Kirsner R. Use of Graftskin in the Treatment of Pressure Ulcers and Acute Wounds. Wounds 2000; 12:72-77.
• Brem H, Balledux J, Bloom T, Kerstein M, Hollier L: Healing of diabetic ulcers and pressure ulcers w+ith human skin equivalent: a new paradigm in wound healing. Archives of Surgery 2000;135:627-634.
• Rosser JC, Prosst RL, Rodas EB, Rosser LE, Murayama M, Brem H. Evaluation of the Effectiveness of Portable Low-Bandwidth Telemedical Applications for Postoperative Followup: Initial Results. J Am Coll Surg. 2000 Aug:191(2):196-203.